Bianca M Liederer Selected Research

GDC-0334

1/2021	A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment.
1/2021	Translational and pharmacokinetic-pharmacodynamic application for the clinical development of GDC-0334, a novel TRPA1 inhibitor.

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Bianca M Liederer Research Topics

Disease

14	Neoplasms (Cancer) 01/2021 - 04/2011
2	Inflammation (Inflammations) 01/2021 - 01/2020
2	Neoplasm Metastasis (Metastasis) 01/2020 - 11/2019
2	Alzheimer Disease (Alzheimer's Disease) 01/2020 - 01/2017
1	Pain (Aches) 01/2021
1	Edema (Dropsy) 01/2021
1	Respiratory Tract Diseases (Respiratory Tract Disease) 01/2021
1	Asthma (Bronchial Asthma) 01/2021
1	Cough 01/2021
1	Arthritis (Polyarthritis) 01/2020
1	Colitis 01/2020
1	Myoclonic Epilepsies (Myoclonic Encephalopathy) 01/2020
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020
1	Brain Neoplasms (Brain Tumor) 11/2019
1	Breast Neoplasms (Breast Cancer) 11/2019
1	Schizophrenia (Dementia Praecox) 01/2017
1	Mental Disorders (Mental Disorder) 01/2017
1	autosomal dominant Spastic paraplegia 6 01/2016
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 10/2013
1	Skin Neoplasms (Skin Cancer) 01/2002

Drug/Important Bio-Agent (IBA)

4	Phosphotransferases (Kinase)IBA 01/2020 - 04/2011
4	Pharmaceutical PreparationsIBA 01/2018 - 04/2011
3	ipatasertibIBA 01/2021 - 04/2013
3	EnzymesIBA 01/2018 - 10/2013
2	GDC-0334IBA 01/2021 - 01/2021
2	Transient Receptor Potential ChannelsIBA 01/2021 - 01/2021
2	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2020 - 01/2017
2	GNE-617IBA 09/2019 - 12/2013
2	NAD (NADH)IBA 12/2013 - 10/2013
2	GNE-618IBA 12/2013 - 10/2013
2	Adenosine Triphosphate (ATP)IBA 04/2013 - 09/2012
1	CollagenIBA 01/2020
1	sharpinIBA 01/2020
1	TOR Serine-Threonine KinasesIBA 11/2019
1	Proline (L-Proline)FDA Link 11/2019
1	salicylhydroxamic acid (SHAM)IBA 11/2019
1	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA 11/2019
1	pyridineIBA 09/2019
1	Nicotinamide PhosphoribosyltransferaseIBA 09/2019
1	GlutaminaseIBA 01/2018
1	Glutathione (Reduced Glutathione)IBA 01/2018
1	Ligases (Synthetase)IBA 01/2018
1	gamma-glutamylcysteineIBA 01/2018
1	Glycine (Aminoacetic Acid)FDA LinkGeneric 01/2017
1	Glutamic Acid (Glutamate)FDA Link 01/2017
1	Ionotropic Glutamate ReceptorsIBA 01/2017
1	Cytochrome P-450 CYP2C9IBA 01/2016
1	Docetaxel (Taxotere)FDA Link 04/2015
1	Methotrexate (Mexate)FDA LinkGeneric 04/2015
1	LipidsIBA 04/2015
1	Fluorouracil (Carac)FDA LinkGeneric 04/2015
1	Doxorubicin (Adriamycin)FDA LinkGeneric 04/2015
1	Topotecan (Hycamtin)FDA LinkGeneric 04/2015
1	Antineoplastic Agents (Antineoplastics)IBA 04/2015
1	Blood Proteins (Serum Proteins)IBA 04/2015
1	Gemcitabine FDA Link 04/2015
1	Niacin (Nicotinic Acid)FDA LinkGeneric 12/2013
1	3- (5- nitrofuryl)- 7- (5- nitrofurfurylidene)- 3,3a,4,5,6,7- hexahydro- 2H- indazoleIBA 10/2013
1	Messenger RNA (mRNA)IBA 10/2013
1	Proteins (Proteins, Gene)FDA Link 10/2013
1	Biomarkers (Surrogate Marker)IBA 04/2013
1	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 09/2012
1	Protein Isoforms (Isoforms)IBA 09/2012
1	Protein Kinase CIBA 09/2012
1	Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)IBA 09/2012
1	N- (4- (3- (1- ethyl- 3- fluoropiperidine- 4- ylamino)- 1H- pyrazolo(3,4- b)pyridin- 4- yloxy)- 3- fluorophenyl)- 2- (4- fluorophenyl)- 3- oxo- 2,3- dihydropyridazine- 4- carboxamideIBA 04/2011
1	epigallocatechin gallate (epigallocatechin-3-gallate)IBA 01/2002
1	AntioxidantsIBA 01/2002

Therapy/Procedure

2	Therapeutics 01/2021 - 04/2013
2	Drug Therapy (Chemotherapy) 04/2015 - 04/2013
1	Oral Administration 04/2013